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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy

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68 Renal pathology is seen in GLP-1 receptor knockout mice due to an increase in glomerular superoxide, an upregulation of renal nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase expression, and a decrease in renal cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activity

Ueda, V

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Additionally, DPP4 inhibitors also exert vascular protective properties, including anti-inflammatory and anti-atherosclerotic effects and the ability to induce vascular relaxation (179, 180)
