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The 2016 LEADER (NCT01179048) trial was the first to demonstrate a modest cardiovascular benefit in patients with T2D and stable cardiovascular disease receiving liraglutide, when compared to placebo

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Figure 1 Statements Author contributions JC, AM, YW, CL, HQ, XM, HY, and LD searched the data, JC, XR, and JZ wrote the main manuscript text

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As the most-studied of the three, semaglutide is commonly used as the baseline comparator when laboratory protocols isolate single- versus multi-receptor signaling