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Retatrutide is a multi-receptor peptide that acts on GLP-1, GIP, and glucagon pathways, influencing appetite regulation, energy expenditure, and metabolic balance

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Rather than prescribing a single fixed dose from the outset, investigators used a gradual escalation model to help participants adapt to the compounds potent triple agonist activity

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They differ in formulation and are prescribed only pursuant to an individualized medical determination by a licensed healthcare provider

These early studies focused on safety, tolerability, pharmacokinetics, and initial pharmacodynamic effects in healthy volunteers and patients with obesity or type 2 diabetes