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Trial participants lost an average of 15-22% of their body weight over 72 weeks, certainly substantial, but this occurred alongside dietary modifications and lifestyle changes

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According to a 2022 study published in The Lancet , patients on tirzepatide experienced an average weight loss of up to 22.5% of their initial body weight over a 72-week period

Participants in clinical studies have reported losing an average of 15 to 20 percent of their body weight over a period of 72 weeks

Beyond weight loss, Tirzepatide improves cardiovascular risk factors, including systolic blood pressure, lipid profiles, and insulin sensitivity