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Semaglutide is an FDA-approved GLP-1 receptor agonist, specifically developed for chronic weight management in adults dealing with obesity or overweight conditions

Clinically detectable appetite suppression and weight changes typically emerge from 0.5 mg onward

Treat adults with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), previously called nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (stages F2 to F3)

Clinicians and patients should consider alternative diagnoses when the pattern deviates from the expected course

Currently, health service patients in Northern Ireland do not have access to specialist weight management provision

Slower titration or lower doses can reduce symptom burden