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Metabolic alterations have been studied in the myocardium of heart failure (HF) patients

A new case report highlights the potential risk of "anhedonia" from high doses of tirzepatide, though it can be treated effectively.

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This review examines the biological mechanisms underlying GLP-1 RA therapy in MASLD/MASH, analyzes the mechanistic distinctions between mono-, dual-, and triple agonists, and synthesizes current clinical evidence supporting their utilization in individuals with this condition.

But their side effects often drive people to stop using them over the long term.
