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Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent
The hyperinsulinemia in ob/ob mice might be caused by the impairment of leptin signaling in pancreatic -cells and contributes to obesity and insulin resistance
Then you look at it from a lifestyle and usage perspective
The physiological effects of GIP and GLP-1 are closely tied to the distribution of their respective receptors in various tissues and organs
2002;54:3439 ( PMID: 12523487 )
