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This occurs due to overall weight loss and preferential mobilization of peripheral fat stores

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Taking a GLP-1 and hitting a weight plateau

However, its clinical benefits are limited by its short half-life, which is less than 2 min because of its small size and rapid enzymatic inactivation by dipeptidyl peptidase IV

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Studies have shown that anywhere from 15 to 60 percent of the weight people lose on GLP-1's is lean muscle.