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Willett, MD, Frank B

While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations

The European Medicines Agency classified NAION as a very rare but recognized side effect of semaglutide in June 2025, affecting up to 1 in 10,000 users

These landmark studies demonstrated that GLP-1 receptor agonists can reduce major adverse cardiovascular events (MACE) in people with established cardiovascular disease or multiple risk factors

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