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Revolutionizing GLP-1 delivery with sublingual administration Recently, a new sublingual modality for GLP-1 receptor agonists (and also for insulins) delivery has been developed by the Dutch company SUBLIN BV, established in 2018 as a spin-out of the healthcare branch of NanoServe BV

Considering the limited number of interventional studies on the effects of GLP-1RA on bone and the lack of sufficient preclinical data, it is reasonable to establish in vitro study to investigate the effects of GLP-1 and GLP-1RA on human bone cells, as well as on bone remodeling in individuals with or without diabetes, in order to ensure the accuracy and credibility of the conclusions

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GCG is a peptide hormone secreted from pancreatic -cells that stimulates hepatic glucose production, thereby maintaining adequate glycemia, but is also involved in hepatic lipid and amino acid metabolism and may increase resting energy expenditure (Habegger et al