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The primary indication for increasing tirzepatide is inadequate therapeutic response, defined as failure to achieve individualized glycemic targets or weight management goals despite good medication adherence and lifestyle modifications

However, humans have far fewer GLP-1 receptors in thyroid C-cells than rodents

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doi: 10.1007/s13300-020-00894-y

Discussion Since 2020, these data suggest strong uptake of GLP-1-based drugs for overweight and obesity, including substantial off-label use of GLP-1 drugs that are approved for T2D only