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Whilst GLP-1 receptors are abundant in the pancreas and gastrointestinal tract, they are also present in various brain regions, including areas involved in mood regulation and emotional processing

Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: a randomized, placebo-controlled trial

More receptor coverage = synergistic effects Appetite suppression (via Y2R) layered onto glycemic control & energy expenditure Smart design: lipidation, sequence grafting, and biasing GLP-1R signaling toward cAMP while avoiding -arrestin desensitization These arent just incremental add-ons

JAMA 2022;327:13850

Tirzepatide addresses the limitations of standalone GIP therapy in diabetes by combining GIPR and GLP-1 receptor (GLP-1R) agonism, leveraging their complementary mechanisms [23]

Many patients prefer weekend days when they have fewer time pressures, whilst others choose a weekday that aligns with other regular commitments