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Description
Both the glucose and anti-inflammatory effect of GLP-1 point to -cell GLP-1 acting locally rather than centrally

For people coming off other GLP-1s (semaglutide or tirzepatide), you have some receptor adaptation already

This article was medically reviewed by Michael Wasef, MD, a board-certified internal medicine physician at Wasef Health, PC, for clinical accuracy and compliance with current guidelines

firemunki December 13, 2023, 3:56pm 12 mcneese.chad: quick hit solution that plenty of people seem to want 20 year old me would never consider it, now Im the wrong side of 40 I could talk myself into it/trt since I dont race sanctioned events and Im mostly racing just myself (and father time), but I a) dont like the unknown risks b) dont have that kinda cash just to ride a bit faster Unless you really need it, I cant see the long term benefits

This hormonal response is why traditional diets feel progressively harder and why weight regain is so common

Research suggests that people who remain on a maintenance dose achieve better long-term results than those who stop completely and restart
