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In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)

Pediatric obesity treatment focuses heavily on family-based lifestyle changes, with medication acting as a support to prevent long-term health complications like early-onset Type 2 diabetes

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doi: 10.1016/j.diabres.2008.03.018

Unlike semaglutide, which only targets GLP-1 receptors, tirzepatide is a dual agonist that targets GLP-1 and glucagon receptors