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The participants performed a comprehensive literature search using prespecified keys (Supplementary Table S2)

Consistent with the metabolic improvements discussed previously, current evidence supports the premise that GLP-1RAs promote SHBG synthesis and reduce bioavailable free androgen activity primarily through weight loss and the alleviation of IR

Oral semaglutide needs to be taken at the morning with 120 mls water, 30 min before any meal intake in order to ensure adequate absorption

Worthington JJ

Some patients also report psychological benefits, including improved mood and motivation, which may relate to achieving weight loss goals and improved self-efficacy

10.1016/j.molmet.2020.101102 59 NeelandI