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Gallstones and gallbladder inflammation become more common with any significant rapid weight loss, regardless of the method

Diabetes Care 2020;43(11):27302735

Results Compared with D&E, semaglutide 2.4 mg in combination with D&E generated an additional 0.1049 QALYs and a 2685 increase in costs over 40 years, resulting in an incremental cost-effectiveness ratio of 25,589/QALY
It is currently available in eight countries - Denmark, Germany, Iceland, Norway, Switzerland, the UAE, the US and the UK - with Japan due to follow at the end of February

A comprehensive evaluation should precede any medication start