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In these trials, participants were randomised to the GLP-1RA in question or placebo, and all participants were treated with standard of care with the possibility of adding non-incretin-based diabetes therapies

De Jayer, D

We need to see how patients fare over several years, not just several months, to truly understand the risk-benefit profile before we can determine its ultimate place in treatment. Having medications like eloralintide, which work through a different mechanism, may provide a vital alternative and increase our ability to personalize treatment for the individual

The primary and secondary endpoints of the study were safety and pharmacokinetic parameters, and fasting serum glucose was measured pre-dose and post-dose in study participants, all of whom had glucose and glycated hemoglobin (HbA1c) levels within the normal reference range for the laboratory

Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

Many people achieve excellent weight loss results at doses below the maximumoften 1.0 mg or 1.7 mg weekly