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[DOI] [PubMed] [Google Scholar] 45.Wharton S, Davies M, Dicker D, et al

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While some indicate an improvement in parameters associated with depression (98), others show an increased risk, especially after longer periods of drug exposure and with the newer drugs with a longer half-life (99, 100), though some other studies indicate a higher risk with liraglutide compared to semaglutide (which in that particular study was associated with reduced risk for psychiatric events) (101)

However, the discontinuation rates for Danuglipron across different doses were over 50%, significantly higher than the approximately 40% observed in the placebo group, indicating poor tolerability in some patients