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FDA has explained: compounded drugs pose a higher risk to patients than FDA-approved drugs, and that the unnecessary use of compounded drugs exposes patients to potentially serious health risks. Lilly has discovered compounded drugs advertised as tirzepatide with safety, sterility, and efficacy problems

GLP-1 receptors are present in brain regions involved in reward processing, including the nucleus accumbens and ventral tegmental area

Regulatory pressure to replace them with low-global-warming-potential (low-GWP) propellants such as HFO-1234ze is building in the EU and UK

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