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Figure 1: Mechanism of Natural GLP-1 in the Joint Environment Source: Created by Haider et al 2026 Discussion Scientists have made a significant breakthrough in arthritis research through their discovery of GLP-1 activity in joint tissues

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An examination of the differentiation of CD4 T cells under diverse conditions, such as those promoting the development of Th1, Th2, Th17 cells, and Tregs, demonstrated that the GLP-1R was most prominently expressed on induced regulatory T cells ( i Tregs) [13]

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