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[DOI] [PubMed] [Google Scholar] 489.Esterhzy, D

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[14] GLP-1 medications at doses licensed for diabetes often produce more modest weight loss of 2-6kg

Some people experience minimal weight reduction with GLP-1s, whereas others have robust weight reductions of 30+%

Patients may need a more careful discussion if they have a history of: Previous NAION in one eye Significant optic nerve crowding Diabetes with vascular complications Sleep apnea, especially untreated sleep apnea High blood pressure or low nighttime blood pressure Cardiovascular disease Sudden unexplained vision loss in the past This does not automatically mean a GLP-1 medication is unsafe, but it does mean the patient should have a personalized risk-benefit discussion with their medical provider

Therefore, to reduce model complexity further, we applied L1 regulation (also called Lasso)