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In conclusion, GLP-1 RAs are an intriguing multitarget treatment option for people with NDs, and future research should focus on optimizing treatment for clinical trials, evolved agonists that can penetrate the central nervous system (CNS), and combination therapies.

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AMPK Activator: An important feature of berberine is its ability to activate AMPK-activated protein kinase in the body's system, which is essential for cellular homeostasis