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Glucagon Activation Increased energy expenditure, hepatic fat oxidation, and basal metabolic rate, expanding the therapeutic mechanism beyond appetite alone

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Across TRIUMPH-1 and TRANSCEND-T2D-1, retatrutide delivered substantial weight loss, meaningful A1C reduction, and improvements in knee osteoarthritis pain and moderate-to-severe obstructive sleep apnea, a breadth and magnitude of outcomes thats striking to see with a single therapy, says Kenneth Custer, PhD, executive vice president and president, Lilly Cardiometabolic Health, in a release

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