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RF-409 is not expected to be universally effective across all classes of IR mutations but is well suited to variants that retain receptor expression and intrinsic kinase activity while being defective in insulin binding or ligand-induced activation, as illustrated by the IR D707A mutation

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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Collagen stimulation: Heat trauma from the laser jump-starts collagen and elastin remodeling for gradual tightening

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