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Finally, participants were filtered on relatedness such that no two people shared more than 700 cM identity by descent 37 , which corresponds approximately to the minimal expected sharing between first cousins in an outbred population, resulting in a final GWAS sample size of 15,237

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This caution is based on findings from animal studies and limited human case reports

doi: 10.1007/S10741-024-10450-6 130 ZhaoXLiuYWangDLiTXuZLiZet al