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Nakagawa, A

The three pathways create synergistic effects that compound over time

Introduction The incidence of carbohydrate metabolism derangements and many cardiovascular and renal complications is increasing [1-4]

There are receptors for GLP-1 in the digestive tract, in the brain, and in the pancreas ( think of receptors as molecular landing pads on the outside of cells where GLP-1 can dock and work its magic )

Furthermore, the review explores novel drug delivery strategies, such as microsphere encapsulation, injectable hydrogels, Fc-fusion, and oral small-molecule formulations, aimed at achieving sustained and controlled release to reduce dosing frequency and improve patient compliance

doi: 10.1161/CIRCULATIONAHA.119.044235