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In addition, GLP-1RA therapy has been associated with favorable shifts in gut microbiota composition, including enrichment of short-chain fatty acid-producing bacteria, which promote Treg activity and suppress pro-inflammatory Th17 responses [43,44]

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Current evidence does not support routine prescribing specifically for Parkinsons disease outside clinical research settings

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

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Finally, with typically older, multi-morbid, obese patients the primary target segment for muscle-preserving therapies, long-term safety and tolerability data, including in polypharmacy situations, are a key prerequisite for their wider adoption, to address lingering concerns about some of the mechanisms of action being explored