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Furthermore, several novel therapeutic compounds (GIP receptor antagonists and agonists including multiple-targeting compounds) have also shown beneficial glucometabolic and body weight lowering effects in individuals with type 2 diabetes and obesity (40, 41)

10.1016/j.vph.2011.05.001 54 FakhouryW

India is home to over 100 million people with diabetes and approximately 250 million classified as obese or overweight.[15] What makes the situation uniquely dangerous is the Thin-Fat Indian paradox: South Asians tend to accumulate more visceral (belly) fat, liver fat, and less lean muscle mass at lower body weights than Western populations.[8][9][10] While GLP-1 medications are a global phenomenon, they are particularly critical for the Thin-Fat Indian phenotype

In one report, patients who lost more than five pounds after starting semaglutide showed reductions in TSH, suggesting that thyroid labs may shift during the early weight-loss phase

Clinical Experiences with GLP1 Agonists in a Weight Management Program In the context of a weight management program, we present a series of case studies that illustrate the potential for GLP-1 agonists to trigger or exacerbate restrictive eating behaviors
Benefits and risks of bariatric surgery in adults: a review