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Orexigenic neurons also located in the ARC express the gene encoding agouti-related peptide (AgRP) and neuropeptide Y (NPY), which reside near the blood brain barrier-lacking median eminence

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The bupropion component carries an FDA boxed warning for increased suicidal ideation in young adults, similar to other antidepressants

It is located on both sides of a single arginine residue (Ugleholdt et al., 2006), but there is also a naturally occurring C-terminally truncated variant, devoid of the last 12 amino acids, GIP(1-30)NH2, which acts as full agonist for the human GIP system (Hansen et al., 2016) and is produced in intestinal and pancreatic -cells by PC2 cleavage of Pro-GIP (Finan et al., 2016)

This is especially useful in managing the typical comorbidity of obesity and type 2 diabetes

POMC, proopiomelanocortin