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It is standard in executive orders to exempt from OMB review rules that pertain to a military or foreign affairs function of the United States, or are limited to agency organization, management, or personnel matters. This order goes further, also exempting regulations that address homeland security or immigration-related functions

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First, the Fc domain can endow hybrid proteins with a longer in vivo circulation time through its interactions with FcRn

In a cost of control analysis by Hansen et al