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Statement development was guided by a systematic literature review and 12 global experts

As obesity is chronic disease patients should understand that antiobesity medication will likely be needed for long-term in majority of them

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is prevalent in more than 50% of patients with type II diabetes

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke

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