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GLP-1 agonists give an average reduction of HbA1c of 11 mmol/mol in comparison with placebo (11) and SGLT2 inhibitors give an average HbA1c reduction of 7-9 mmol/mol (12)

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Table 3 summarizes the pooled data on the gastrointestinal adverse reactions observed in the SURPASS-1 to SURPASS-5 studies for T2D therapy in comparison to placebo ( Table 3 Pooled gastrointestinal adverse events associated with tirzepatide treatment in the SURPASS 1 and SURPASS 5 studies compared to comparator treatment in type 2 diabetes ( Comparable to observations during treatment with GLP-1RA, symptom-free elevations of pancreatic enzyme concentrations for amylase and lipase were seen in the above-mentioned SURPASS studies ( Further adverse events observed with tirzepatide treatment included sinus tachycardia associated with a concomitant increase from baseline in heart rate of 15 beats per minute (4.6%10.0% vs