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GLP-1s reliably reduce energy intake and create steady weight loss in both clinical and preclinical research

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doi: 10.1016/j.metabol.2019.154031

SURPASS-1 shows that tirzepatide alone, at all doses, was superior to placebo and revealed a dose-dependent reduction of HbA1c by up to 2.07% (p 10% weight loss can be disease modifying and may even lead to disease remission [38]

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Patients should be informed that psychotherapy, particularly CBT adapted for BED, has the strongest evidence base and should typically be considered first-line treatment