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Nat Rev Endocrinol 14 , 390403 (2018)

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Glucagon-like peptide-1 receptor agonist therapy in patients with type 2 diabetes and advanced CKD: Kidney and cardiovascular outcomes in a real-world setting

For most patients, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) require long-term use to maintain their benefits

In a systematic review of 24 randomized controlled trials (age 419 years), metformin resulted in modest decreases in BMI (range of mean values: 2.70 to 1.30 vs