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Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

Sixth, extensive subgroup analyses without formal adjustment for multiple comparisons raise the possibility of type I errors

The risk appears to be rare, and the evidence is not fully settled

Enthusiasm around these therapies has outpaced awareness of what is and is not compliant in sterile preparation, and that gap creates real patient-safety risk
