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Mering and Minkowski's findings encouraged Gustave-douard Laguesse, a French histologist and pathologist, to theorise in 1893 that the pancreatic islets described by Langerhans produced an endocrine secretion (Hoet)

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7 The direct effects on the central nervous system and the weight loss contribution to ICP reduction were a pleasant finding in a randomized, placebo-controlled, double-blind trial in which IIH patients in the exenatide group experienced a significant reduction in ICP both immediately and after 12 weeks of follow-up, along with nearly eight fewer headache days across the 12 weeks