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Its likely that GLP-1 RAs (or their combinations) will be part of a future MASH therapy regimen, given weight loss is the cornerstone treatment and GLP-1 causes weight loss plus some direct hepatic fat reduction

CrossRef Lean or Non-obese Nonalcoholic Fatty Liver Disease Patients: Are They Really Lean

Call 911 or proceed to the nearest emergency department immediately if experiencing: chest pain or pressure lasting more than a few minutes or that resolves and returns

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The drug is being developed by Eli Lilly and Company, which has announced plans to progress retatrutide into Phase 3 clinical trials across multiple indications, including obesity, type 2 diabetes, and liver disease

Data with more than two independent groups were analyzed by one-way ANOVA with Bonferronis multiple comparison post-hoc test