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You cant do a [randomized clinical trial] on all cancer types, following patients for 20 years

Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas)

Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)

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Commonly reported side effects include mild injectionsite redness, transient headache, flushing, or shortterm fatigue

However, the combination requires monitoring because weight loss-driven reductions in blood volume and metabolic demand may lower blood pressure beyond the therapeutic target