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Trastuzumab-targeted biodegradable nanoparticles for enhanced delivery of dasatinib in HER2+ metastasic breast cancer
Pathological processes such as oligodendroglial insulin signaling defects, glial inflammation, mitochondrial stress, and impaired proteostasis overlap with pathways modulated by GLP-1R stimulation
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While cardiovascular death alone didn't reach statistical significance (middle-left panel), consistent directional benefits appeared across heart failure outcomes and all-cause mortality, suggesting broad cardiovascular protection
The Grb7-SH2 domain plays a critical role as an interaction site, especially for peptides featuring a pYXN motif in a turn conformation, where pY represents phosphotyrosine
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