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27,28 Outside of vascular smooth muscle, the mechanisms by which GLP-1 action can reduce kidney injury are likely multifactorial, 29,30 reflecting that multiple tissues are contributing to improvements

Berard L, Bonnemaire M, Mical M, Edelman S
Most weight loss occurs within the first 68 to 72 weeks of treatment, but some people notice appetite changes within a few weeks

N Engl J Med (2013) 368:40715

The dynamics of switching once are fundamentally different from switching back and forth every few months
