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Expected local reactions include slight redness, mild tenderness, and occasional minor bruising at the injection site

A more recent study by Aronne and colleagues investigating the differences in weight loss using phentermine alone vs in combination reported weight loss of 5.1% at 28 weeks

By analysing tirzepatide's effectiveness as an adjunctive therapy rather than monotherapy, our study design reflects practical clinical scenarios and provides valuable insights into optimising IIH management strategies [5, 8]

This can provide faster initial absorption compared to subcutaneous injection, but the overall pharmacokinetic profile once the drug reaches systemic circulation is the same