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GLP-1 RA glucagon-like peptide 1 receptor agonists, CI confidence interval, MACE major adverse cardiovascular event, MI myocardial infarction, SBP systolic blood pressure in mmHg, HR hazard ratio, RR relative risk, HF heart failure, LVEF left-ventricular ejection fraction a Primary or secondary outcome of interest as reported by the study Statistically significant confidence interval Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

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This gradual titration was specifically designed to mitigate the nausea, vomiting, and diarrhea that occur more frequently with rapid dose increases

This led to semaglutide being recommended for diabetics with cardiovascular disease, even before it was widely marketed, and it solidified the idea that GLP-1 RAs have a class benefit on the heart

However, most of these events were mild to moderate and temporary

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