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Combined activation of both receptors may act synergistically providing additive effects on glucose and body weight in comparison of GLP1 analogues alone

As previously mentioned, they stabilize mitochondrial function and reduce oxidative stress, and inflammation by inhibiting signaling pathways, such as NF- B, thereby contributing to cellular homeostasis during sepsis (41)

These pathways play a critical role in enhancing cell survival and inhibiting apoptosis in pancreatic -cell, thereby showcasing multifaceted protective effects of GLP-1 RAs on -cell viability

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Sachar, D

But the longer answer involves understanding what actually causes plateaus and whether timing plays any role