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Nature (2012) 490(7418):5560

"Weight-loss jabs investigated for suicide risk"

The dose is then gradually increased for each following week, as follows: week two: 1.2 mg per day week three: 1.8 mg per day week four: 2.4 mg per day weeks five and beyond: 3 mg per day If you have bothersome side effects after a dose increase, talk with your doctor

Currently, Wegovy is FDA approved for the following: Children ages 12 years or older with a body mass index (BMI) at or above the 95th percentile for their sex and age Adults with a BMI at or above 30 Adults with a BMI at or above 27 and at least one weight-related health condition, such as heart disease, diabetes, high blood pressure, or sleep apnea Adults with a BMI at or above 27 with established cardiovascular disease and a risk of major adverse cardiovascular events (like heart attack or stroke) Adults with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis Note that there are slightly different prescribing rules for Wegovy pills versus Wegovy injections

Boehringer Ingelheim maintains niche loyalty for dulaglutide via its auto-injector design, though share erosion is visible

Neuroprotective actions of GLP-1 receptor agonists: an emerging role in antidepressant therapy