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Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)

Diabetes Technology & Therapeutics, 24 (11), 789796

They deliver substantial, sustained weight loss by curbing appetite and overall food intake, which can improve blood pressure, lipids, sleep apnea risk, mobility, and quality of life

Furthermore, a sedentary lifestyle is associated with a greater risk of HFpEF compared with HFrEF (Pandey et al., 2016)

a RWD: real-world data from cohort or registry studies (electronic health records, insurance-claims databases), b SRS: adverse drug reaction evidence from case reports and spontaneous-reporting systems, such as the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and World Health Organization (WHO) VigiBase

Possibly, particularly in the first three to six months