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doi: 10.1007/s12035-017-0550-2 [DOI] [PubMed] [Google Scholar] 140

Sustained release strategy designed for lixisenatide delivery to synchronously treat diabetes and associated complications

The slowing of food transit through the digestive system affects the entire gastrointestinal tract, not just the stomach

Discussion In this study, leveraging non-viral LNPs and the HITI-mediated genome editing method, we engineered a secretion-enabled Exe4 peptide, scExe4, and developed an in vivo scExe4 peptide production reservoir via knock-in into mouse liver cells

doi: 10.1111/dom.14775 [DOI] [PMC free article] [PubMed] [Google Scholar] 201.Gastaldelli A, Cusi K, Fernndez Land L, et al

Disproportionality analysis A sequential approach was adopted to systematically address major confounders: (1) An exploratory disproportionality approach comparing GLP-1RAs with all other drugs reported in the FAERS database, using venlafaxine as the positive control and empagliflozin/orlistat as the negative control