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Cardiovascular outcomes included hospitalization for heart failure (HHF), all-cause mortality, HHF plus all-cause mortality, myocardial infarction (MI), stroke, and modified major adverse cardiovascular events (MACEs)

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Lancet Diabetes Endocrinol 2018;6:275286

Typically, these medications are started at a low dosage, which is gradually increased to a maintenance level, allowing the body to tolerate any potential side effects

Medication interactions : Concurrent use of certain medications can increase stone risk, including topiramate, acetazolamide, triamterene, indinavir, high-dose vitamin C, and some vitamin D supplements

Many patients benefit from indefinite or intermittent use rather than stopping abruptly