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For differential expression testing, the R package DESeq2 (v.1.30.1) was used to identify differentially expressed genes

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Figure 3 Neddylation of cullin RING ligases is a promising molecular target to restore defective IL-2R signaling in Tregs We recently identified a druggable defect in the IL-2R signaling pathway of Tregs from patients with autoimmune diseases (62)