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If you lose significant muscle mass while on Tirzepatide, your Basal Metabolic Rate (BMR) drops

Mounjaro should be used with caution in patients with severe gastrointestinal disease, such as gastroparesis

Oral and sublingual formulations are promising but are still establishing their efficacy profiles through ongoing research

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The strategy was, therefore, to identify GLP-1 mimetic drugs with a molecular structure close enough to native GLP-1 to stimulate the GLP-1 receptor, but with alterations that enabled prolonged activity by, in particular, possessing resistance to breakdown by DPP-4 (Meier, 2012)