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1,3 It also decreases glucagon secretion

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Exendin-4 has been extensively tested in combination with other drugs 44,45,46,47,48,49,50 in mouse models of diabetes

According to the SmPC, these include: Nausea usually mild to moderate and often diminishing over time Vomiting and diarrhoea which can contribute to dehydration if not managed appropriately Abdominal pain and decreased appetite reflecting the medication's effect on gastric emptying and satiety signals Constipation affecting some patients, particularly those with reduced food and fluid intake Severe gastrointestinal symptoms can lead to dehydration, which may precipitate acute kidney injury in some patients